T1AM-bound mTAAR1-Gs protein complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8jlj
Q-score: 0.543
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ Pubmed: 37935376 DOI: doi:10.1038/s41586-023-06804-z ]
- T1am-bound htaar1 (Complex from Mus musculus)
- Soluble cytochrome b562,trace amine-associated receptor 1 (50 kDa, Protein from Mus musculus)
- Htaar1-bound t1am in complex with gs heterotrimer (Complex)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Mgs (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gs heterotrimer (Complex from Homo sapiens)
- 4-[4-(2-azanylethyl)-2-iodanyl-phenoxy]phenol (355 Da, Ligand)
Ulotaront(SEP-363856)-bound mTAAR1-Gs protein complex
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8jlk
Q-score: 0.387
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ Pubmed: 37935376 DOI: doi:10.1038/s41586-023-06804-z ]
- T1am-bound htaar1 (Complex from Mus musculus)
- Soluble cytochrome b562,trace amine-associated receptor 1 (50 kDa, Protein from Mus musculus)
- Htaar1-bound t1am in complex with gs heterotrimer (Complex)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Mgs (41 kDa, Protein from Homo sapiens)
- 1-[(7~{s})-5,7-dihydro-4~{h}-thieno[2,3-c]pyran-7-yl]-~{n}-methyl-methanamine (183 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gs heterotrimer (Complex from Homo sapiens)
T1AM-bound hTAAR1-Gs protein complex
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8jln
Q-score: 0.427
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ Pubmed: 37935376 DOI: doi:10.1038/s41586-023-06804-z ]
- Htaar1-bound t1am in complex with gs heterotrimer (Complex)
- Soluble cytochrome b562,trace amine-associated receptor 1 (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Mgs (43 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gs heterotrimer (Complex from Homo sapiens)
- T1am-bound htaar1 (Complex from Homo sapiens)
- 4-[4-(2-azanylethyl)-2-iodanyl-phenoxy]phenol (355 Da, Ligand)
Ulotaront(SEP-363856)-bound hTAAR1-Gs protein complex
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 8jlo
Q-score: 0.473
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ Pubmed: 37935376 DOI: doi:10.1038/s41586-023-06804-z ]
- Soluble cytochrome b562,trace amine-associated receptor 1 (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- 1-[(7~{s})-5,7-dihydro-4~{h}-thieno[2,3-c]pyran-7-yl]-~{n}-methyl-methanamine (183 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gs heterotrimer (Complex from Homo sapiens)
- Htaar1-bound sep363856 in complex with gs heterotrimer (Complex)
- Sep-bound htaar1 (Complex from Homo sapiens)
Ralmitaront(RO-6889450)-bound hTAAR1-Gs protein complex
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 8jlp
Q-score: 0.433
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ Pubmed: 37935376 DOI: doi:10.1038/s41586-023-06804-z ]
- 5-ethyl-4-methyl-~{n}-[4-[(2~{s})-morpholin-2-yl]phenyl]-1~{h}-pyrazole-3-carboxamide (314 Da, Ligand)
- Soluble cytochrome b562,trace amine-associated receptor 1 (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Gs (43 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gs heterotrimer (Complex from Homo sapiens)
- Ral-bound htaar1 (Complex from Homo sapiens)
- Htaar1-bound ral in complex with gs heterotrimer (Complex)
Fenoldopam-bound hTAAR1-Gs protein complex
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 8jlq
Q-score: 0.426
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ Pubmed: 37935376 DOI: doi:10.1038/s41586-023-06804-z ]
- Htaar1-bound t1am in complex with gs heterotrimer (Complex)
- Soluble cytochrome b562,trace amine-associated receptor 1 (54 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Mgs (43 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gs heterotrimer (Complex from Homo sapiens)
- T1am-bound htaar1 (Complex from Homo sapiens)
- (1r)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine-7,8-diol (305 Da, Ligand)
A77636-bound hTAAR1-Gs protein complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8jlr
Q-score: 0.462
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ Pubmed: 37935376 DOI: doi:10.1038/s41586-023-06804-z ]
- A7736-bound htaar1 (Complex from Homo sapiens)
- Soluble cytochrome b562,trace amine-associated receptor 1 (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Mgs (41 kDa, Protein from Homo sapiens)
- Htaar1-bound a77636 in complex with gs heterotrimer (Complex)
- Gs heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- (1~{s},3~{r})-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1~{h}-isochromene-5,6-diol (329 Da, Ligand)
AMPH-bound hTAAR1-Gs protein complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8jso
Q-score: 0.439
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ Pubmed: 37935376 DOI: doi:10.1038/s41586-023-06804-z ]
- Htaar1-bound amphetamine in complex with gs heterotrimer (Complex)
- Soluble cytochrome b562,trace amine-associated receptor 1 (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- Scfv16 (Complex from Mus musculus)
- Mgs (41 kDa, Protein from Homo sapiens)
- Gs heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Mus musculus)
- Amphetamine-bound htaar1 (Complex from Homo sapiens)
- (2s)-1-phenylpropan-2-amine (135 Da, Ligand)
Ulotaront(SEP-363856)-bound Serotonin 1A (5-HT1A) receptor-Gi complex
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 8jsp
Q-score: 0.411
Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z
Nature (2023) 624 pp. 672-681 [ Pubmed: 37935376 DOI: doi:10.1038/s41586-023-06804-z ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (4 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from Mus musculus)
- 5-hydroxytryptamine receptor 1a (42 kDa, Protein from Homo sapiens)
- Htaar1-bound t1am in complex with gs heterotrimer (Complex)
- 5ht1a in complex with gi heterotrimer (Complex from Homo sapiens)
- 1-[(7~{s})-5,7-dihydro-4~{h}-thieno[2,3-c]pyran-7-yl]-~{n}-methyl-methanamine (183 Da, Ligand)
- Scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (35 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of C5a-bound C5aR1 in complex with Gi protein
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7y64
Q-score: 0.498
Feng Y, Zhao C, Deng Y, Wang H, Ma L, Liu S, Tian X, Wang B, Bin Y, Chen P, Yan W, Fu P, Shao Z
Cell Res (2023) 33 pp. 312-324 [ Pubmed: 36806352 DOI: doi:10.1038/s41422-023-00779-2 ]
- Scfv16 (28 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- C5a anaphylatoxin (8 kDa, Protein from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- C5a-bound c5ar1 (Complex from Homo sapiens)
- C5a-bound c5ar1 in complex with gi heterotrimer (Complex)
- Gi heterotrimer (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- C5a anaphylatoxin chemotactic receptor 1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)